Studying the seismic dynamic responses of loess-mudstone slope is important for the slope stability evaluation and engineering aseismatic design. The effects of seismic wave amplitude on the seismic dynamic responses of loess-mudstone slope are investigated by the centrifuge shaking table tests and numerical simulation. Results show that: the amplification of horizontal and vertical acceleration of loess mudstone slope increases nonlinearly from deep to shallow surface of the slope. The horizontal amplification is greater than the vertical

and it reaches the maximum value at the crest. The dynamic response of the loess layer is larger than that of the mudstone inside the slope. With the increasing of the amplitude of the input seismic wave

the dynamic response of the slope increases first and then decreases. When the input amplitude reaches 0.3g

the dynamic response of the slope reaches the maximum value. The deformation and failure process of the loess-mudstone slope could be summarized as: with the input of seismic wave amplitude increasing

tension crack formed at the crest

gradually expands

displacements develop towards the free face

and then overlying loess raises lightly

some soil accumulats at the slope toe.