靶向TSPO的神经炎症成像分子探针

臧小豪; 刘起发; 胡蒙蒙; 常媛媛; 肖清炜; 周渭

doi:10.12052/gdutxb.190090

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靶向TSPO的神经炎症成像分子探针

更新时间：2026-05-27

- 靶向TSPO的神经炎症成像分子探针
- Molecular Probes Targeting TSPO for Neuroinflammatory Imaging
- 广东工业大学学报 2020年37卷第4期页码：91-97
- 作者机构：
  
  广东工业大学生物医药学院,广东,广州,510006
- 作者简介：
  
  臧小豪(1995–)，男，硕士研究生，主要研究方向为基于TSPO的神经炎症荧光分子探针合成与评估
  周渭(1987–)，男，副教授，主要研究方向为基于药物代谢性质的神经炎症抑制剂的结构优化与抗阿尔茨海默症药效学研究, E-mail：zhou_wei@gdut.edu.cn
- 基金信息：
  
  国家自然科学基金青年基金资助项目(81502911)
- DOI：10.12052/gdutxb.190090
  中图分类号： R749.16
- 纸质出版：2020
- 稿件说明：
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臧小豪, 刘起发, 胡蒙蒙, 常媛媛, 肖清炜, 周渭. 靶向TSPO的神经炎症成像分子探针[J]. 广东工业大学学报, 2020, 37(4): 91-97.

Zang Xiao-hao, Liu Qi-fa, Hu Meng-meng, et al. Molecular Probes Targeting TSPO for Neuroinflammatory Imaging[J]. 2020, 37(4): 91-97.
臧小豪, 刘起发, 胡蒙蒙, 常媛媛, 肖清炜, 周渭. 靶向TSPO的神经炎症成像分子探针[J]. 广东工业大学学报, 2020, 37(4): 91-97. DOI： 10.12052/gdutxb.190090.

Zang Xiao-hao, Liu Qi-fa, Hu Meng-meng, et al. Molecular Probes Targeting TSPO for Neuroinflammatory Imaging[J]. 2020, 37(4): 91-97. DOI： 10.12052/gdutxb.190090.

摘要

神经炎症贯穿神经退行性疾病的整个发病过程。在正常的生理状态下

神经炎症有助于神经系统损伤的修复

但当炎症反应过度时则会造成细胞的损伤

加速神经退行性疾病的恶化。当神经炎症发生时

小胶质细胞会异常活化。这使它们成为反映小胶质细胞病理生理学改变的一种敏感而特异的定量指标。本文主要通过核素和可见光成像技术对神经炎症靶点进行检测

介绍了近年来TSPO靶点分子探针的研究进展

包括核素成像和荧光成像。最后展望了神经炎症分子探针的研究方向

对于开发更清晰、方便、经济的神经炎症分子探针有一定的借鉴意义。

Abstract

Neuroinflammation runs through the whole course of neurodegenerative diseases. In normal physiological state

nerve inflammation contributes to the repair of nervous system damage

while excessive inflammation can cause cellular damage

accelerating the deterioration of neurodegenerative diseases. When nerve inflammation occurs

microglia cells are activated

which makes them a sensitive and specific quantitative indicator to reflect the pathophysiological changes of microglia cells. Nuclide and visible light imaging technologies were used to detect neuroinflammatory targets

and the research progress of molecular probes targeting TSPO targets in recent years was introduced

including nuclide imaging and fluorescence imaging. Finally

the application prospect and market value of the neuroinflammatory molecular probes are summarized and forecasted

which is of certain reference significance for the development of novel neuroinflammatory molecular probes.

关键词

Keywords

references

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