星状pH响应聚合物及其自组装胶束研究

羊惠燕; 郭建维

doi:10.12052/gdutxb.180056

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星状pH响应聚合物及其自组装胶束研究

综合研究 | 更新时间：2026-05-27

- 星状pH响应聚合物及其自组装胶束研究
- A Study of Star pH-Responsive Polymer and Its Self-Assembled Micelles
- 广东工业大学学报 2019年36卷第1期页码：81-86
- 作者机构：
  
  广东工业大学　轻工化工学院,广东,广州,510006
- 作者简介：
  
  羊惠燕(1991–)，女，硕士研究生，主要研究方向为功能高分子材料
  郭建维(1968–)，男，教授，博士生导师，主要研究方向为功能高分子材料. E-mail：guojw@gdut.edu.cn
- 基金信息：
  
  广东省自然科学基金资助项目(2016A030310349);广州市科技计划项目(201704030075,201604010015)
- DOI：10.12052/gdutxb.180056
  中图分类号： TQ317.4
- 网络首发：2019-01-25，
  
  纸质出版：2019
- 稿件说明：
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羊惠燕, 郭建维. 星状pH响应聚合物及其自组装胶束研究[J]. 广东工业大学学报, 2019, 36(1): 81-86.

Yang Hui-yan, Guo Jian-wei. A Study of Star pH-Responsive Polymer and Its Self-Assembled Micelles[J]. 2019, 36(1): 81-86.
羊惠燕, 郭建维. 星状pH响应聚合物及其自组装胶束研究[J]. 广东工业大学学报, 2019, 36(1): 81-86. DOI： 10.12052/gdutxb.180056.

Yang Hui-yan, Guo Jian-wei. A Study of Star pH-Responsive Polymer and Its Self-Assembled Micelles[J]. 2019, 36(1): 81-86. DOI： 10.12052/gdutxb.180056.

摘要

研究了一种星状聚合物——金刚烷基聚己内酯−

−聚甲基丙烯酸二乙氨基乙酯−

−聚甲基丙烯酸单甲氧基聚乙二醇酯(Ad-(PCL-

-PDEAEMA-

-PPEGMA)

)及其自组装胶束以用于阿霉素(DOX)递送. 采用ROP和ARGET ATRP方法合成该聚合物

其自组装胶束具有良好的稳定性(CMC=3.4 mg/L); DOX负载胶束在pH=5.0下的释放速率明显快于pH=7.4和pH=6.8. 结果表明

pH响应Ad-(PCL-

-PDEAEMA-

-PPEGMA)

胶束可作为抗癌药物靶向递送的潜在载体.

Abstract

A star-shaped polymer adamantane-[poly(ε-caprolactone)-

-poly(2-(diethylamino)ethyl methacrylate)-

-poly(poly(ethylene glycol) methyl ether methacrylate)

]

(Ad-(PCL-

-PDEAEMA-

-PPEGMA)

) and its pH-responsive self-assembled polymeric micelles were developed for adriamycin (DOX) delivery. This star-shaped polymer was synthesized via ring-opening polymerization (ROP) and activators regenerated by electron transfer atom transfer radical polymerization (ARGET ATRP)

and characterized by

H NMR spectroscopy

gel permeation chromatograph (GPC)

fluorescen

ce spectra and dynamic light scattering (DLS). The resulting polymer had a definite structure with a narrow molecular weight distribution (PDI1.3); the critical micelle concentration (CMC) of the polymer was very low (3.4 mg/L)

which indicated that the polymeric micelles would keep stable in blood circulation system; resulting from the protonation of the tertiary amine group of PDEAEMA

the release performance of micelles at pH = 5.0 were rapider than that at pH=7.4 and pH=6.8. The results shows that pH-responsive Ad-(PCL-

-PDEAEMA-

-PPEGMA)

micelles could be a potential carrier for targeted delivery of anti-cancer drugs with controlled and sustained release behavior.

关键词

Keywords

references

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