The spatial model of element regular and symmetrical frame-shear wall structures is established，and the elasto-plastic seismic response of structures under uni-and bi-directional seismic excitation is analyzed．The analysis results，including maximum displacement of comer columns，maximum story drift，time—history curves of vertex aeceleration and time-history curves of vertex displacement，are compared．It is found that RC frame．wall structureswill suffer qreater damage under bi-directional seismic excitation than uni-directional seismic excitation．It is difficult to reveal the true seismic performance of structures under the actual earthquake only trough the uni-directiona dynamic analysis．