Tumor becomes one of the major killers to human health.Although the conventional microsecond pulse irreversible electroporation has been widely applied in solid tumor therapy and achieved great effects because of the non-thermal ablation

some problems still need to be solved with the clinical process

such as incomplete ablation due to the non-uniform distribution of electric field and muscle contraction during treatment.The clinical demands give rise to a new generation irreversible electroporation—composite pulse irreversible electroporation.In this paper

we firstly introduced the development of the traditional irreversible electroporation and its problems

then the appearance of composite pulse

especially

the development and the achievement of composite pulse were described.Secondly

the design of the composite pulse apparatus and the first clinical trial on human prostate in the world by Chinese researchers were mentioned

which verified the safety and efficiency of composite pulse in tumor ablation.Finally

we pointed out the application prospect and development tendency of composite pulse irreversible electroporation.