Abstract: In view of the growing security requirements in the operation of current thermal power plant, the construction of intelligent security system and the application of intelligent equipment and information technologies have become the up-to-date development trend of safety monitoring and management in thermal power plant so as to ensure the maximum security and reliability of the operations as well as the safety of personnel at the workplace. By identifying major hazard sources and analyzing requirements of safety monitoring and management upgrade, the overall framework and application functionalities of intelligent security system are presented on account of requirement analysis result. Further analysis and research are conducted and elaborated regarding the application and its practical value appreciation with new intelligent security technologies for major hazard sources. Meanwhile suggestions on maintaining the advancement of intelligent security system are also provided.