Abstract: An ORC system coupled with double vortex tubes (DVT-ORC) is proposed to make full use of the energy of the waste heat and pressure of air in industrial production and reduce the condensation heat loss of the ORC system. The waste heat and pressure air after heat release is separated into cold and hot air by the heat source vortex tube; the cold air is used for cooling the working fluid; the hot air is used as the heat source of the second evaporator; and the waste pressure after heat transfer is used to drive the pneumatic booster pump. The exhaust gas of the turbine is separated into cold and hot streamers by a working fluid vortex tube. The hot streamer is recirculated by a pneumatic booster pump and the cold streamer is fed into an air cooler for cooling. Using the air of 150℃ and 0.6 MPa as the heat source, R245fa as working fluid, and multi-objective optimization models based on thermodynamics and economics are established to analyze the effects of cold flow ratios of double vortex tubes and the turbine exhaust pressures on the comprehensive performance of the DVT-ORC system. And optimization using a genetic algorithm is performed to determine the optimal operating conditions. The results show that when the cold flow ratio of the heat source vortex tube is greater than 0.3, the output work of the DVT-ORC is larger than that of the basic ORC, the sum of exergy losses of working fluid vortex tube and air cooler can be reduced by at most 1 240.32 kW compared to that of the condenser of the ORC system, and the levelized energy cost of DVT-ORC system is lower, so the thermal and economic performances of the DVT-ORC system are improved. The DVT-ORC system works best when the exhaust pressure of the turbine is 0.300 7 MPa, the cold flow ratio of the working fluid vortex tube is 0.873 8, and the cold flow ratio of the heat source vortex tube is 0.894 2. The corresponding net output work is 173.94 kW, the thermal efficiency is 13.57%, and the levelized energy cost is 0.415Yuan/(kW·h).