Abstract: Based on the carrier of coconut shell activated carbon and active components of manganese nitrate and ferric nitrate, carbon-based catalyst modified by Mn-Fe oxides was prepared by using a combined methods of nitric acid oxidation, constant volume impregnation, and medium-low temperature calcination. NO reduction of as-prepared carbon-based catalysts was carried out in a fixed-bed reactor. The mechanism of NO reduction and its resistance to SO₂ and water by carbon- based catalyst was discussed on the basis of measurements of Fourier transform infrared spectroscopy (FT-IR), N₂ adsorption-desorption, SEM-mapping and XPS. The obtained results indicate that Mn modification can effectively enhance NO reduction efficiency of carbon-based catalyst. And the addition of Fe and Mn not only improves NO reduction of carbon-based catalyst, but also makes window temperature downward to 120℃. The optimum loading capacity of Mn-Fe carbon-based catalyst is 7%Mn and 0.5%Fe, and the combined calcination with nitrogen calcination at 400℃ and air calcination at 200℃ is an optimal calcination method. The addition of Fe can effectively promote the uniform distribution of Mn on the surface of the carbon-based catalyst, and significantly increase the contents of Mn⁴⁺ and surface adsorbed oxygen (O_α). Under the conditions of 6% O₂ and without water and SO₂, NO reduction efficiency of 7Mn0.5Fe/HAC catalyst reaches 82.0% at 120℃, and can be stable at 95% at 140-240℃. Mn-Fe carbon-based catalyst has a good resistance performance to SO₂ and moisture. NO reduction efficiency of 7Mn0.5Fe/HAC catalyst can reach more than 85% under the conditions of temperature of 180℃, 100μL/L SO₂ and 6% moisture in the simulated flue gas.