Abstract: The problem of efficient and clean utilization of excess pyrolyzed semi-coke is a huge challenge. The antibiotic filter residue is a kind of biomass solid waste, which also requires proper disposal or resource utilization. In order to solve the co-disposal and resource utilization of semi-coke and antibiotic filter residue, a semi-coke and filter residue staged co-combustion scheme was proposed in this paper, and the Aspen Plus process simulation software was used to simulate the behavior of semi-coke and filter residue in staged oxy-fuel co-combustion. The results show that an increase in the blending ratio of semi-coke in oxy-fuel co-combustion increases the total amount of flue gas and the amount of CO₂ generated. The volume fraction of CO₂ increases, and the contents of H₂ decrease. The co-combustion process of solid fuel in air and O₂/Ar atmospheres is similar and the total flue gas flow is almost the same, which is less than that in oxyfuel atmosphere. As the oxygen concentration increases, the total flue gas flow decreases; the volume fractions of CO₂ and H₂O increase. Increasing the blending ratio of semi-coke and oxygen concentration can promote the combustion of fixed carbon and improve the combustion characteristics, while the oxy-fuel combustion is conducive to CO₂ enrichment and emission reduction. It is proved that the co-disposal of semi-coke and filter residue by oxy-fuel combustion can realize the effective utilization of solid waste resources.