Abstract: The research significance, state-of-the-art development, challenges and key scientific problems of the energy-cyber-transportation-social coupling network based complex network analysis was reviewed. Based on the theory of self-organization, the energy self-organization (ESO) was defined. By analyzing the complex characteristics of ESO individuals and clusters, the differences and advantages between ESO and similar concepts studied in many literatures were summarized and compared, and the theoretical system of complex network analysis application in regional energy internet was improved. Through the elaboration of ESO individual and cluster complex network modeling, optimal network flow distribution, synchronous control, cascading failure mechanism analysis and interests interactive game research idea and method, energy- cyber-transportation-social coupling network dynamic evolution characteristics such as independent autonomy, self-optimization and self-adaptation can be revealed and enhanced. Finally, the prospect of research was prospected.