Abstract: Under the background of carbon peak and carbon neutrality, the clean and low-carbon development of coal power is an inevitable trend. Coal coupling combustion of biomass, sludge, household waste and other renewable fuels for power generation can significantly reduce CO₂ emissions, which is one of the ways for coal-fired power plants to achieve carbon neutrality and carbon peak. After coal is mixed with renewable fuel for power generation, the types and contents of unconventional pollutants (trace elements, VOCs, etc.) in flue gas will increase. Therefore, it is particularly necessary to study the removal capacity of existing air pollutant control devices (APCDs) in coal-fired power plants and the multi-pollutant collaborative control technology that can be used in coal-fired power plants in the future for unconventional pollutant emission reduction. Based on the emission characteristics of non-conventional pollutants in the flue gas after mixing combustion, this paper focuses on the summary and analysis of its migration and transformation rule and purification effect in the environmental protection equipment of APCDs, and expounds the progress of the improved process technology for more efficient control of non-conventional pollutants. Furthermore, the development status, technical problems and engineering application of the collaborative removal of pollutants technology are discussed, and its scale development still faces many technical challenges. In the future, coal-fired power plants can achieve the goal of "reducing pollution and carbon" by coupling renewable fuel generation with collaborative control of pollutants and CO₂ capture, utilization and storage technology.