Abstract: Interference cancellation is an active way of interference management method, and its core idea is to use interference sources to eliminate interference. For the high-speed frequency hopping system, the anti-jamming system using a separate method to design interference cancellation system requires customized RF front-end design. Aiming at the anti-interference suppression requirements of the anti-interference system of the high-speed frequency hopping system, the workflow of the frequency hopping data link interference cancellation system is analyzed from four aspects: signal sampling, RF access, cancellation mode and control interface. The pass-through unit and RF front end of the main control antenna front-end circuit are designed, and the noise power density and noise power are calculated by combining the influence of analog-to-digital conversion (AD) noise floor and the peak average ratio of interference signal. The constraints of RF front-end parameters affecting the sensitivity of frequency hopping data link and the upper limit of interference cancellation capacity are analyzed. Finally, the optimization analysis of the gain and signal bandwidth parameters of the RF front-end system affecting the frequency hopping data link interference cancellation system is given.