Abstract: Public transport hub (PTH) is an important urban transport infrastructure and also the coupling node of urban energy-transport system. How to realize the coordinated development of PTHs and urban distribution systems, reduce the negative impact of electric bus load, and harness operational flexibility to promote the quality and efficiency improvement of power system has become an important issue. In this paper, considering the contribution of PTH's demand response under normal and contingency conditions respectively, a multi-layer collaborative planning approach for highly reliable urban distribution system empowered by PTH flexibilities is proposed. Incorporating multi-domain constraints, the model optimizes PTH location/configuration, distribution system expansion and multi-mode operation, realizing efficient utilization of PTH flexibilities and reliable/economical operation of the distribution system. A multi-layer Benders decomposition method is proposed to transform it into a three-layer iterative model to achieve accurate and efficient solution. Finally, with the modified IEEE 33-bus distribution system and actual data of Sihui PTH, the effectiveness of proposed model and approach is verified.