Abstract: In recent years, to promote renewable energy consumption and improve energy efficiency, the integrated energy system (IES) has been widely promoted and applied. Establishing a refined integrated demand response (IDR) model is the key to realize the coordinated and optimized operation of IES. In this paper, a regional IES architecture with coupling between energy supply and demand was first constructed. Then, based on the elastic price response model of power load, a refined IDR model with coupling response characteristics of electricity-heat-cold demand was established. On this basis, with the goal of minimizing the operating cost of IES, the IES optimization operation model was established. This model achieved the coordinated optimization on both sides by optimizing the energy price of on the demand side and the operating parameters of the energy conversion equipment in the EH on the supply side. Finally, based on a regional IES system, the IDR model and IES operation model were simulated, and the results show that the proposed IDR model can accurately describe the coupling response characteristics of the participation in demand response, and the proposed IES optimal operation model can improve the economy of IES and promote the renewable energy consumption.