Abstract: To control the pollutant emission of CO more effectively, the perovskite-type catalysts LaMn_1-xCu_xO₃ (x=0, 0.2, 0.4, 0.6, 0.8) with different Cu²⁺ doping amount were synthesized by flame spray synthesis (FSS) method. The structure and catalytic activities of catalysts were characterized and analyzed. The catalysts synthesized by FSS method exhibit good perovskite phases, regular shape, good thermal stability, and redox characteristics. Compared with other methods, the catalysts prepared by FSS method perform higher catalytic activities. The specific surface area (SSA) and oxidability of catalysts are improved with the increase of Cu²⁺ doping from 0.2 to 0.6. When the doping amount reaches the maximum value of 0.8, the perovskite structure is damaged and SSA decreases. LaMn_0.4Cu_0.6O₃ catalyst performs the highest activity and the CO conversion reaches 50% at 157.4℃ and 90% at 178.6℃. The catalysts exhibit good catalytic activities in consecutive oxidation cycles. In consecutive oxidation experiments with LaMn_0.4Cu_0.6O₃, the CO conversion reaches 50% at 169℃ and 90% below 200℃ in the eighth oxidation cycle. It turns out that the FSS method can further improve the activity of catalysts and is suitable for the preparation of efficient catalysts for CO oxidation.