Abstract: Large-scale wind power connected to the grid will bring about problems of the real-time power balance and economical operation in microgrid (MG). To address the above problem, this paper proposed a MG economic scheduling strategy considering the deep response of the water supply system (WSS). Firstly, the WSS was divided into several independent subsystems to decrease the constraints and release the regulation flexibility. Furthermore, considering the stability constraints of the node water pressure, a multi-time-scale response model of the WSS was established. On this basis, considering peak load regulation and frequency modulation demands of the external power grid, a MG economic dispatching strategy was designed. Finally, linearization was used to solve the model efficiently. The simulation results on the 15-node WSS and typical MG show that the WSS can reduce the MG operational costs. This paper supplies a novel perspective of solving the problem of renewable consumption.