Abstract: The single multi-energy microgrid is constrained by the energy type and capacity, it is difficult to fully realize the efficient use and coordinated control of multiple energy sources for independent operation. To solve this problem, this paper established a microgrid cluster coordination and optimization operation model that can improve the electricity-gas networks regulation capability based on the multi-energy microgrid. Firstly, a multi-type microgrid unified model containing multiple energy types including electricity, heat, cold, hydrogen, and gas was established. Then an energy exchange model between microgrids based on unified model was established. A multi-energy microgrid cluster system optimized operation strategy suitable for the electricity-gas networks regulation demand was proposed. With the multi-energy microgrid cluster system's minimum operating cost and maximum energy utilization efficiency as the optimization goals, and a improved regional local search NSGA-Ⅱalgorithm (NSGA- Ⅱ-RLS) was used to solve the microgrid cluster optimization model. Finally, based on the improved IEEE14 node system and natural gas network 6-node system structure, a multi energy microgrid cluster operation simulation model The results of simulation show that the ME-MCS proposed in which can enhance the operation and regulation ability of power and gas networks was established. this paper can effectively improve the electricity-gas networks regulation ability and realize the multi-energy complementary operation of the ME-MCS.