Abstract: The model of two-nozzle spray in wind tunnel was established by Fluent 18.2 in this paper. The effects of the two-nozzle distance, inlet air velocity, inlet air dry-bulb temperature and relative humidity on evaporative cooling performance were investigated. The results show that the corresponding maximum scale of drop in temperature of 0.6, 1.0, 1.4 m distance between two nozzles is 7.8℃, 7.4℃ and 7.4℃, respectively, and the corresponding maximum area of cooling affected zone is 1.49 m2, 1.62 m2, 1.59 m2, respectively. The inlet air velocity is recommended to be 2～3 m/s. High dry bulb temperature and low relative humidity are conducive to evaporation cooling, but they are subject to local environment. For the evaporation cooling process of two-nozzle model, it is necessary to analyze it combined with the heat transfer rate, average temperature, area of cooling affected zone and the length of the wind tunnel. The proper nozzle distance should be selected combined with the goals of good cooling uniformity, large cooling temperature drop and small amount of nozzles, to design the spray evaporation cooling system reasonably according to different application occasions, requirements and sites.