Abstract: The aerodynamic performances of large wind turbine towers are significantly affected by blade interference and yaw condition. Taking the 5 MW wind turbine as the example, the flow field and aerodynamic forces of the wind turbine tower considering six yaw angles（0, 5, 10, 20, 30 and 45 degrees） were simulated by large eddy simulation method, and the numerical simulation results were compared with standard curves to verify the validity of the numerical method. On this basis, the average wind pressure, pulsating wind pressure, lift coefficient, drag coefficient and flow of the wind turbine tower under different yaw angles were systematically analyzed. The results show that with the increase of the yaw angle, the maximum negative pressure and the extreme negative pressure of the disturbed section decreased first and then increased, the layer resistance coefficient increased gradually, the maximum negative pressure, extreme negative pressure and layer resistance coefficient of the undisturbed section had no obvious changes. With the increase of height of the disturbed section, the layer resistance coefficient decreased first and then increased under different yaw angles. Comprehensive analysis show that the aerodynamic performance of the tower was the most unfavorable at 0 degrees yaw angle, with the increase of the yaw angle, the influence of the flow and wake around the tower was weakened, when the yaw angle was 45 degrees, the aerodynamic force of the tower was close to that when it was not disturbed. The research conclusions can provide scientific basis for the wind load design of large wind turbine tower under the condition of yaw.