Abstract: Through the separation and decoupling of the working process of the organic Rankine cycle, the thermodynamic performance expressions of the working fluid are derived by using the critical temperature, acentric factor in the physical properties of the working fluid and the cycle parameters, and then the thermodynamic model of the cycle is established. With the help of this model, the influence of the cycle parameters on the thermodynamic performance evaluation index of the cycle is analyzed. The research results show that as the evaporation temperature increases, the cycle thermal efficiency increases, but its net output power and exergy efficiency grows first and then decrease. When the condensation temperature increases, the thermal efficiency, net output work, and exergy efficiency of the cycle will all decrease. When the degree of superheat increases, the net output power and exergy efficiency decrease, while the cycle thermal efficiency increases. Based on the introduction of Jacobian number based on the physical properties of the working fluid, the net output power and exergy efficiency show an increasing and decreasing trend with the increase of Jacobian number, respectively. The higher the critical temperature, the higher the thermal efficiency.