Abstract: In this paper, the constitutive parameters are determined based on the triaxial test data, and the finite element model of the field test and the centrifuge test is established. The applicability of the SANISAND constitutive model to pile-soil interaction under static, seismic, and cyclic loads is investigated in order to provide a reference for its engineering design application. The results indicate that the SANISAND constitutive model can well reproduce the pile top load-displacement characteristics of different pile diameters under horizontal static loads, the variation trend of acceleration and pore pressure time history curves under earthquakes, and the pile deformation performance under short-term cyclic horizontal loads. However, it is not possible to accurately reproduce the negative peak pore pressure caused by dilatation as well as the cumulative deformation under long-term cyclic loads.