Abstract: Aiming at the problems encountered in the numerical simulation of the existing wind turbine wake using computational fluid dynamics method（CFD）of large number of grids and large computional resource requirments,this paper proposes a numerical simulation method of wind turbine wake using two-dimensional agent model,and applies this agent model to the layout optimization of wind farms. Firstly,the wake flow of a single wind turbine is simulated numerically,and the simulation results are tested according to the field measurement data. Secondly,the agent model is applied to the wind farm simulation of multiple wind turbines to analyze the tailing effect of the wind turbine under different incoming wind angles. Finally,the annual power generation of multiple equidistant rectangular arrangement wind farms is calculated by combining the wind speed and wind direction rose plot,and the relationship between the angle between the wind farm and the N（north）direction and the annual power generation of the wind farm is analyzed.Simulation results show that the field measured data and simulated data are highly correlated,which verifies the feasibility of the twodimensional agent model and the accuracy of the calculation results. When the angle between the wind farm and the N（north）direction is in the range of 0° to 40°,the annual power generation of the wind farm when the angle is greater than 0° is greater than that when the angle is equal to 0°. When optimizing the layout of wind farms,choosing the angle between the appropriate wind farm and the N（north）direction is conducive to improving the annual power generation of the wind farm and improving economic benefits.