Abstract: In order to decrease the high energy consumption of the conventional membrane distillation（MD）technology,a novel Nanophotonics-enabled solar membrane distillation（NESMD） is proposed to substitute the MD,and its overall thermodynamic performance was studied through analyzing the key operational parameters influence on overall thermodynamic performance. The investigation results show that the volume heating to heat the feed liquid causes the temperature polarization and the correspondingly high energy consumption of MD component,and the NESMD component adopts the surface heating to heat the feed liquid,and there is no temperature polarization,so it demonstrates significant energy-saving advantages. Under the same feed temperature and feed speed,the temperature polarization coefficient and thermal efficiency of NESMD component are significantly improved compared with MD module. The thermal efficiency of NESMD component is most affected by of solvent latent heat,and the low feed speed and high feed temperature can be adopted to improve its thermal efficiency. When PVA coating is used as power input section,and the maximum thermal efficiency values are achieved at the optimal input section length for both NESMD and MD components. NESMD module has better expansibility and longer active length than these of the MD module. The above performance laws provide a scientific basis for further optimizing the structure.