Abstract: The sluggish kinetic of oxygen reduction reaction（ORR） at the cathode of the fuel cells makes the platinum（Pt） as the stateof-the-art electrocatalyst,which limits the large-scale application of fuel cells. It is thus particularly urgent to develop the low-cost,highperformance and practical ORR electrocatalysts. In this paper,the research progress of Pt and non-Pt electrocatalysts for current practical and future development is reviewed based on our previous research in practical electrocatalysts towards ORR for many years.The synthesis strategy of Pt-based electrocatalysts with high metal loading,high activity,excellent structural stability and efficient expression of performance in fuel cells are emphasized. At the same time,the rational design and controllable synthesis of non-Pt carbonbased materials are elaborated. In addition,the further development of this research field is prospected to accelerate the localization of fuel cells.