Abstract: A bionic flow channel based on nautilus structure is proposed and a three-dimensional single phase,isothermal CFD numerical model is established for multi-physical field simulation in present study. The inlet of the flow channel is located in the center,the reactants enter from the center of the flow channel and flow to the surrounding annular flow channel in turn. The traditional serpentine flow channel and the nautilus bionic flow channel are simulated and analyzed. It is found that nautilus bionic flow channel has more uniform distribution of reactants,better water removal,less loss of concentration polarization and better output performance.Compared with the serpentine flow channel,the peak current density increases by 46.77% and the peak power density increases by 21.53%.