Abstract: The work proposes a real-time control strategy for a cryo-compressed hydrogen supply system. It is used to manage and control the hydrogen storage and supply process in fuel cell trucks. Firstly,the establishment of cryo-compressed hydrogen discharging model is based on fluid thermodynamic model to predict state parameters of hydrogen. Secondly,a novel cryo-compressed hydrogen supply system is designed combined with on-board thermal management system. It is a comprehensive use of‘heat energy’from fuel cells and‘cold energy’from cryo-compressed hydrogen. Finally,based on numerical simulation,quantitative research on operation parameters for heat exchangers is conducted and control strategy is optimized. The overall dynamic response mechanism not only meets requirements for normal operation,but also improves energy utilization of whole vehicles.