Abstract: Optimization program of the wind turbine blade has been developed based on the PSO algorithm in this manuscript. The program is embedded into the main program of the FAST by using the MATLAB Simulation interface to realize the interaction between the blade optimization program and FAST. The simulation goal aims at realizing the maximum power output and completing the automatic aerodynamic shape optimization of the wind turbine blade. The simulation method not only takes the influence of the actual sea condition and the deployment of the platform on the optimization result into consideration,but also considers the influence of the wind direction distribution. The optimization results at low wind condition showed that the power output of the optimized wind turbine has increased 1.5%. The weighted optimization result showed that the power output has increased 3.8% when the wind direction distribution is considered.