Abstract: The integrated regional energy system,which is composed of electric/gas/heat/cold and other energy sources,can unify the planning and dispatching of grid power,natural gas and distributed energy,and realize the complementary advantages of different energy sources,it is the important direction of future energy system development. The scheduling model of the integrated regional energy system was built,which contains wind,light,gas,electricity,heat,and cold. The model takes the minimum cost of the integrated energy system as the objective function subjected to the power supply,heat（cold）supply balance and operation of micro gas turbine.According to the "thermal power setting" and "electricity fixed heat" modes,four scenarios are set in the summer and winter seasons,the scheduling model is solved under the four scenes by using the cuckoo search algorithm to obtain the output of each participant in the integrated regional energy system under the four scenarios,and the operation cost of the regional integrated energy system under the four scenarios is compared and analyzed. Finally,the model is solved by traditional particle swarm optimization and genetic algorithm,and the results are compared with those obtained by cuckoo search algorithm. The results demonstrate the validity of the proposed model and algorithm,and get a more suitable running strategy,which provides a new method and approach for the economic dispatch of the regional integrated energy system.