Abstract: The basin modeling method for evaluation of oil-gas resources has been widely paid attention and plays an important role in the exploration and development of hydrocarbon resources because of its ability to quantitatively express evaluation results and high work efficiency. At present, basin modeling method faces with three challenges, including that the classical petroleum system theory from source to trap cannot effectively guide the evaluation of unconventional oil-gas resources, that the application of basin numerical simulation technology cannot be effectively expanded to complex tectonic evolution areas, and that it is difficult to predict the evaluation results of oil-gas resources and characterize the comprehensive risk of reservoir development. The establishment of whole petroleum system theory and the proposal of quantitative evaluation methods have opened up new ideas and approaches to address current challenges. The combined genetic model and mutual constraint mechanism of conventional and unconventional oil-gas resources were elaborated using the whole petroleum system theory, and further a study was carried out based on basin numerical simulation and the statistical simulation of drilling results. On this basis, six key technologies were proposed for predicting and evaluating the comprehensive risks of conventional oil and gas, tight oil and gas, shale oil and gas, oil-gas sweet spots, hydrocarbon amount destroyed by tectonic events, and oil-gas resources in whole petroleum system, and application examples were also listed. The results show that the new theories and technologies of whole petroleum system can not only predict the formation and distribution of oil-gas resources, but also evaluate the amount of oil-gas resources and their drilling and exploitation risks, creating conditions for establishing a new generation of basin modeling system with independent intellectual property rights.