Abstract: Through the comprehensive interpretation of the latest drilling, logging and seismic data in the deep water area of Qiongdongnan Basin, in combination with the numerical simulation of the basin, this paper carries out a research on the main controlling factors of hydrate accumulation in the study area, and establishes an accumulation pattern of gas hydrate in the deep water area of Qiongdongnan Basin. The results show that gas source rocks, pathway systems, hydrate stabilization zones, mass transport deposition systems (MTDs), and differences in reservoir lithologies are important factors that control the formation and enrichment of gas hydrates. The Paleogene source rocks and shallow organic matters in Qiongdongnan Basin can provide sufficient gas sources. The network pathway systems formed by the combination of diapir structures, gas chimneys and faults controls the migration and accumulation of hydrocarbons and the formation of gas hydrates. MTDs in coarse sediments and hydrate stabilization zones can create favorable reservoir conditions and caprock conditions for gas hydrate enrichment and accumulation. The comprehensive analysis suggests that gas migration pathways and MTDs are the most critical factors for controlling the formation of gas hydrate deposits with high gas saturation. Deep structures and the areas where MTDs are relatively developed and close to hydrocarbon-generating sags are favorable areas for gas hydrate accumulation with high gas saturation.