Abstract: Based on the reservoir-wellbore coupling relation of horizontal well completed by taking the horizontal well as open hole, two coupling models including no flow boundary and constant pressure boundary reservoirs were built up. For the two coupling models, the new optimization models for the separated production scheme in the horizontal wells were developed, taking the length and location of horizontal intervals as research objects. On the premise that oil production is the largest, the most optimized scheme for planning intervals of the horizontal wells is proposed by using the genetic algorithm. The change rules of oil production were discussed with the change of parameters such as thickness of layer and operation time. The plots of typical curves are given,which are useful for the separated production scheme of horizontal wells.