Abstract: With the rapid development of the nuclear power industry,spent fuel management has become one of the key issues restricting the development of nuclear power. Spent fuel storage methods include wet storage and dry storage. At present,NUHOMS system has been introduced in China for dry storage. The vacuum drying process of NUHOMS spent fuel dry storage technology is introduced,the problems existing in the process of vacuum drying are especially analyzed,such as poor purging effect,unreasonable pipeline layout,boron crystallization blockage of pipelines and so on,and the corresponding optimization suggestions and measures are put forward.