Abstract: Based on the climate data and geographic information data of Hutubi county and its surrounding 15 meteorological stations from 1980 to 2020, the spatial simulation model of index factors such as ≥10 ℃ accumulated temperature, frost-free period, average temperature in July, ≥15 ℃duration, ≥20 ℃ accumulated temperature were constructed by geostatistical regression and inverse distance weight. Combined with the index grade of cotton zoning, the refined climate zoning of cotton planting was finally obtained. The zoning results show that the whole county was divided into four zones:the suitable zone, the sub-suitable zone, the risk zone and the unsuitable zone. The suitable planting area was in the northern plain area of Hutubi county with an altitude below 510 m, including the plain area of Yuanhu village, 111 regiment, 105 regiment, 106 regiment and Fangcaohu farm. The sub-suitable area was in the vicinity of Wukui Expressway in Hutubi county with an altitude of 510 m to 650 m, including Hutubi town, Shilidian town, Wugongtai town and the plain areas in the north and south sides of Dafeng town. The risk cotton area was in the piedmont sloping plain at the south of Hutubi county with an altitude of 650 m to 850 m. The non-cotton area was at the area with the altitude above 850 m.