Abstract: A Smith predictor with parameter identification based on differential evolution algorithm combined precise feedforward control scheme was proposed. The design parameters were used to accurately feed forward the main disturbance quantity through enthalpy calculation to ensure the anti-disturbance ability of the system. The actual operation data was collected, and the mathematical model of the object was identified based on the improved differential evolution algorithm to improve the modeling accuracy, so as to improve the compensation accuracy of Smith predictor. The results of simulation and practical application showed that the optimized control system had good stability, fast response and control accuracy, which completely accorded with the actual requirement of the project.