Abstract: A new programme of high-voltage power grids self-healing is put forward.Based on that, a new high-voltage power grid self-healing scheme is proposed.The collections of protective trip information, i.e.action set of each fault point, are initially utilized to establish an expert knowledge base in advance.When a fault happens, the action set will be formed according to the action information of breakers and protections gathered by a power grid control center.Then, it will be compared and contrasted with the action set in the expert knowledge base to determine the fault point.A 220 kV smart grid control center in east China grid with a fault on its high-voltage power grid is taken as an example.The idea of high-voltage power grid self-healing is put forward, and the issues that need attention are summarized for prevention and tuning control during the self-healing process.The process of employing the expert knowledge base to identify the fault point, fault isolation and power grid restoration, are presented and then testified with the results from video technologies.The example shows that the proposed scheme can meet the requirement of grids self-healing.It can isolate a fault automatically and quickly, and then restore the non-fault part.This proposed approach can fulfill as a good reference for the construction of smart grids at the moment.