Abstract: Aiming at the problems of poor anti-interference and low monitoring accuracy of the existing intelligent monitoring system of power grid operation data, a new architecture of distribution automation monitoring system is proposed. The system uses the distribution system state estimator（DSSE） of integrated analog circuit as the key component of the monitoring system. The developed DSSE optimizes the unit of the distribution network monitoring system, performs real-time monitoring in the substation, and can be coordinated through multi region state estimation algorithm to improve the time efficiency and robustness of monitoring events, while maintaining an acceptable accuracy level. In addition, this study designs an experiment for false noise signal injection protection. The experimental results show that the system has high stability against such attacks and effectively ensures the quality of power grid operation data.