Abstract: The instability and intermittency of renewable energy output have increased the difficulty of participating in electricity market trading and quotation.Regional integrated energy systems can reduce their quotation deviation in the market, improve energy utilization efficiency, and contribute to the stable operation of the system and market by scheduling the internal energy of the system.This paper considers equipment such as wind power, energy storage, electricity-to-gas conversion, and micro gas turbines, as well as load side demand response, to construct a regional comprehensive energy system that participate in the optimization and scheduling strategy of the electricity and natural gas market operations.Firstly, a relationship matrix is established to describe the complementary conversion relationship between energy sources such as electricity, heat, and natural gas in the regional comprehensive energy system; Secondly, considering the uncertainty of wind power output, a regional comprehensive energy system optimization scheduling model based on two-stage robust optimization is constructed, further involving the comprehensive energy system as a market entity in electricity and natural gas market transactions.Finally, the example verifies that internal scheduling of regional integrated energy systems can reduce the impact of wind power output deviations, improve system stability and economy.