Abstract: In the process of achieving the carbon neutrality goals, green hydrogen production from renewable energy will become a crucial driving force for deep decarbonization and green substitution across multiple industries. Leveraging renewable energy bases to develop large-scale hydrogen production and utilization systems has attracted widespread attention both domestically and internationally. However, existing studies on green hydrogen lack a comprehensive analysis of structure configuration methods, operational strategies, and key technologies for large-scale renewable energy power to hydrogen (ReP2H) systems. To address these issues, firstly, this paper systematically reviews the typical configurations of ReP2H systems and analyzes structure configuration methods suitable for large-scale ReP2H systems. Secondly, this paper reviews the current research status of integration systems and clarifies the development trends to meet the new demands of wide-range, rapid, and efficient operation of water electrolysis systems. Thirdly, in response to the policy associated with the grid integration of large-scale ReP2H systems, this paper summarizes the typical operation strategies of both grid-connected and off-grid systems. Finally, this paper explores key technologies essential to ensuring the safe, stable, and efficient operation of ReP2H systems.