Abstract: In response to the voltage quality issues caused by the high proportion of distributed photovoltaic integration into the distribution network, this paper proposes a voltage layered coordinated control strategy for medium- and low- voltage distribution networks based on photovoltaic inverter regulation. Firstly, the voltage control methods of active distribution networks were analyzed, and a voltage interval partition control method for photovoltaic inverters was proposed. Then, a dual layer control architecture for medium- and low-voltage distribution networks is constructed, and an optimized control model is constructed with the goals of minimizing network losses, voltage deviations, and maximizing distributed power consumption. Finally, the IEEE 33 node example and a practical distribution network example were used to validate the hierarchical control strategy of the active distribution network. The IEEE 33 node example shows that the optimization method can be adopted to reduce the overall loss of the distribution network by 3.79% and the voltage deviation rate by 27.29%. The computation results show that the optimization method can be adopted to reduce the overall loss of the distribution network by 36.33%, reduce the voltage deviation rate by 62.59%, and effectively improve the photovoltaic absorption and balance ability, ensuring the safe and stable operation of the active distribution network.