Abstract: The continued expansion of renewable energy sources such as wind and solar power poses a serious threat to the safe and stable operation of power systems. The further exploration of load-side regulation potential provides new regulation tools for frequency regulation, peak regulation and emergency control of the power system. Focusing on the key challenges of multi-physics coupling, and strong time-variability and weak observability in load control, we review the key technologies for multi-level cooperative regulation of direct-controlled loads under new power systems, including continuous adaptive active regulation technology, safe and refined graded excision technology, and multi-timescale interactive control technology for two types of loads, namely centralized thermal storage industrial loads and distributed distribution network feeder loads. In view of the above, the prospects in key technical difficulties are put forward in conjunction with literature research results, and the application of some technologies in demonstration projects is introduced.