Abstract: In order to enrich the electromagnetic protection method, a novel protection method based on the novel mechanism is explored. Based on the Lyapunov stability theory and Routh-Hurwitz criteria, the stability of Hodgkin-Huxley neuron model (named HH neuron model) is studied. The analytical condition for the parameters of HH neuron model is derived. The performance of resisting the electromagnetic interference is assessed by way of the correlation coefficient and the Taguchi orthogonal method. The parameters of HH neuron model are optimized to achieve the stronger ability of resisting the electromagnetic interference. It is found that the values of parameters are limited to guarantee the stability of HH neuron model. The HH neuron model has the performance of resisting the electromagnetic interference. The optimized parameters of the HH neuron model can improve the electromagnetic anti-interference performance. The research results can be adopted to provide the important guidance for designing the bio-inspired circuit based on the anti-interference mechanism of neuron.