Abstract: The strong and frequent lightning activities in Guangdong have seriously impaired the safe operation of the power grid, the lightning protection situation of the power grid is severe. To elaborately protect the lightning activities in areas with strong lightning activities can bring significant safety and economic benefits to the power grid. Therefore, in this paper, based on the idea of active and regional lightning protection, the temporal and spatial clustering algorithms and comparative statistical analysis methods are used to study the changes in lightning parameters and thunderstorm processes for several years before and after the artificial lightning intervention of the lightning tower in Foshan (a city in Guandong province of China), and the active and regional lightning protection effects of the lightning tower array in the lightning corridor are evaluated. It has been found that, after the completion of the lightning tower, the frequency of ground flashes and the amplitude of lightning currents show an upward trend. The lightning tower will increase the number of strong lightning and ground lightning activities in the surrounding area to a certain extent, and bring it closer to the tower. The proportion of lightning activity moving to tower increases, and the lightning current amplitude of lightning activity after passing the lightning tower is reduced. In addition, the operation results show that the active lightning protection and regional lightning protection effects of the lightning tower arrays in Foshan are very significant. The active and regional lightning protection technology for power grids based on the artificial lightning intervention of lightning tower is scientific and feasible, and it is necessary to deepen the research and application in the future.