Abstract: In view of urban waste reduction in "Zero-Waste City" development model and the problem of weak regulation ability of power grid and gas network in high proportion renewable energy urban multi-energy system, a multi-energy system optimal model in which power grids, gas networks and waste disposal are coordinately taken into consideration is proposed. Firstly, an energy supply and demand model of waste disposal facilities is established to meet the needs of urban multi-time scale of waste disposal, and a topology model of waste reduction multi-energy system (WRMES) is proposed. Then, a WRMES coordination optimization model is established for waste minimization and the optimization of system operation, and it is solved by multi-objective evolutionary algorithm based on decomposition. Finally, based on the waste stockpile and multi-energy operation data of a city in northeast China, the WRMES optimization simulation model is established. The simulation results show that WRMES can rapidly reduce large-scale urban waste, effectively reduce the operation costs of multi-energy systems, and effectively improve the flexibility of power grid and gas network regulation.