Abstract: The application of organic Rankine cycle（ORC）has outstanding advantages with low-temperature waste heat recovery in boiler. For a 330 MW coal-fired boiler, an ORC power generation system with low-temperature waste heat recovery was designed for power supply within station, and following indicators were calculated, such as the auxiliary power consumption rate, thermal efficiency of power supply, standard coal consumption rate of power supply, carbon emissions intensity of power supply and payback period. After which, an analysis was conducted on the economy of the boiler coupled with ORC power generation system. Results show that, with the application of the boiler coupled with ORC power generation system, the average auxiliary power consumption rate is decreased by 0.18 percentage points, the average thermal efficiency of power supply is increased by 0.07 percentage points, the average standard coal consumption rate of power supply is decreased by 0.7 g/（kW·h）, the average carbon emissions intensity of power supply is decreased by 1.52 g/（kW·h）, and the payback period of this technology is 7.04 years. The technology of boiler coupled with ORC power generation system through low-temperature waste heat recovery has certain economic benefits.