Abstract: Aiming at the uncertainty caused by largescale wind power grid-connected to system frequency modulation, a cloud model load frequency control strategy considering the uncertainty of wind power was proposed. Firstly, the wind power output was regarded as the disturbance signal, and the regional control deviation composed of the wind output power and the power deviation of the tie line was regarded as the input of the load frequency controller. According to the cloud model rule generator, the cloud PI load frequency controller with uncertainty mapping relationship was established. Taking the three-area interconnected power grid with wind power as an example, the simulation analysis of the measured data in a certain regional power grid showed that the established cloud PI controller can better track the fluctuations of the wind output power and has strong anti-interference. The method proposed not only satisfies the requirements of the frequency modulation for wind power connected to the grid, but also has better control effect than traditional PI controller.