Self-assembled NIRF/MRI Dual-modality Contrast Agents for Rat Bone Stem Cell (RBMSC) Tracking

Liu Hong; Tan Yan; Han Ya-li; Wang Zhi-yong

doi:10.3969/j.issn.1007-7162.2016.04.011

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Self-assembled NIRF/MRI Dual-modality Contrast Agents for Rat Bone Stem Cell (RBMSC) Tracking

更新时间：2026-05-27

- Self-assembled NIRF/MRI Dual-modality Contrast Agents for Rat Bone Stem Cell (RBMSC) Tracking
- Vol. 33, Issue 4, Pages: 62-68(2016)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.1007-7162.2016.04.011
  CLC：
- Online First：02 August 2016，
  
  Published：2016
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刘鸿, 谭燕, 韩雅莉, 王志勇. 自组装近红外/磁共振双模态造影剂用于大鼠骨干细胞示踪[J]. 广东工业大学学报, 2016, 33(4): 62-68.

Liu Hong, Tan Yan, Han Ya-li, et al. Self-assembled NIRF/MRI Dual-modality Contrast Agents for Rat Bone Stem Cell (RBMSC) Tracking[J]. 2016, 33(4): 62-68.
刘鸿, 谭燕, 韩雅莉, 王志勇. 自组装近红外/磁共振双模态造影剂用于大鼠骨干细胞示踪[J]. 广东工业大学学报, 2016, 33(4): 62-68. DOI： 10.3969/j.issn.1007-7162.2016.04.011.

Liu Hong, Tan Yan, Han Ya-li, et al. Self-assembled NIRF/MRI Dual-modality Contrast Agents for Rat Bone Stem Cell (RBMSC) Tracking[J]. 2016, 33(4): 62-68. DOI： 10.3969/j.issn.1007-7162.2016.04.011.

摘要

制备了适用于磁共振成像（MRI）和近红外成像（NIRF）的双模态造影剂，用于大鼠骨间充质干细胞的标记和示踪.以乙酰丙酮铁(III)、1

2-十六烷二醇、油酸和9-十八烯胺等为原料，通过热分解法制备单分散、粒度均匀的超顺磁氧化铁(SPIO)纳米粒子.再以硬脂酸修饰的聚乙烯亚胺(stPEI)为表面活性剂，通过自组装制备了同时携带SPIO和近红外染料IR-780的MRI和NIRF的双模态造影剂stPEI-SPIO/IR-780.经透射电镜、动态光散射、MRI和小动物活体成像仪系统表征显示该造影剂具有较合适的粒径、表面电势和出色的成像效果，用其标记、示踪大鼠骨髓间充质干细胞也表现出了很好的生物相容性和成像效果.

Abstract

In order to combine the advantages of magnetic resonance imaging (MRI) with near-infrared fluorescence (NIRF) imaging

a dual-modality contrast agent is prepared based on MRI and NIRF

which could be used for labeling and tracking rat bone mesenchymal stem cells (RBMSCs). Superparamagnetic iron oxide (SPIO) nanocrystals are prepared by Fe(acac)3

2-hexadecanediol

oleic acid

and oleylamine via thermal decomposition method

which posses monodisperse property and uniformly size. Then the contrast agents are used for magnetic resonance imaging (MRI) and near-infrared fluorescence (NIRF) imaging by wrapping the SPIO nanocrystals and IR-780 dye with stearic acidmodified polyethylenimine (stPEI) self-assembly. Transmission electron microscopy (TEM) and dynamic light scattering (DLS) are used to characterize the size and zeta potential

and MRI and IVIS Spectrum System used to characterize the imaging capability. The result shows that the contrast agents are reasonably nano-sized and positively charged. Moreover

the dual-modality contrast agent has showed effective bio and imaging compatibility for labeling and tracking rat bone mesenchymal stem cells (RBMSCs) both in vitro and in vivo.

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