In the fractured-vuggy reservoir unit

the water injection mainly affects the oil well unidirectionally and is easy to advance rapidly along the main channel

leading to the problems of difficult to effective control the water drive reserves and low efficient production. By the methods of physical model and numerical simulation

the relation between the structure of fracture/cave and the development effect of water flooding in different karst background is analyzed

and the differential injection-production relation based on the spatial distribution of fracture/cave is formed. The results show that: in the crust karst reservoirs

the mode of water injection in the low part and oil production in the high part of the structure

and water injection in the undeveloped area and oil production in the developed area is adopted to establish the injection-production relation of one injection well to multiple production wells. In the fracture-controlled reservoirs

the mode of water injection in the secondary fault and oil production in the main fault

and water injection in the deep fracture area and shallow for oil production in the longitudinal direction is adopted to form the stereoscopic injection-production relation. In the ancient underground river reservoirs

the water injection in the main section and oil production in the branch are implemented in the main dark section

and the water injection in deep and oil production in shallow are implemented in multiple dark rivers

so as to establish the layered injection-production relation. The establishment of injection-production relation in different karst backgrounds of fractured-vuggy reservoirs lay an important foundation for maximizing water drive controlled reserves of spatial well pattern.