The seismic response of a reinforced concrete continuous rigid frame bridge is analyzed considering the scattering of SV seismic waves by canyon topography. The differences of structural responses between uniform and nonuniform seismic excitation cases are revealed. The results indicate that the canyon topography has significant and complex effects on the seismic response of the bridge. Different structural members suffer critical responses in different analysis cases. The low piers and rigid frames are more sensitive to the nonuniform ground motions obtained from the seismic response analysis of canyon topography in the case of oblique incidence of SV waves; otherwise the flexible high piers are insensitive. Canyon topography effects as well as the incidence angle of the waves should be regarded as important factors taken into account in aseismic design.