The antimicrophyte effect of the compound plant medicine in ultrasonically-enhanced transdermal drug gel is studied. The transdermal drug contained the compound with Chinese Angelica
Fleeceflower Root
Lonicera japonica Thunb
Aloe and L-menthol. Compounding so many plant medicines resulted in a significantly increased antimicrophyte effect
which might be due to accumulative effect plus analternation action.The experimental results show that the rate of sterilizing both Escherchia coli and Staphlococus aureus allare is more than 99 percent
and the rate of sterilizing Trichophyto rubrurn is 85.27 percent
but the rate of sterilizing candida aibicans is only 62.11 percent. The grade of outbody cytotoxicity test ranks the first
and the test result is in accordance with the official specification of China.
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references
Rainer H Muller.现代给药系统的理论和实践[M].胡晋红,译.北京:人民军医出版,2004.
Mitragotris S,Kost J,Langer R,et al,Determination of threshold endrgy dose for ultrasonnd-induced ransdermal drug transport[J]. J contr Rel,2000,63:41-52.
Lipkovker L M. Ultrasonic transdermal drug delivery system[P]. 世界知识产权组织PCT专利 (WIPO): wo 94/08655.1994-04-28.
裘炳毅.化妆品化学与工艺技术大全(上册)[M].北京:中国轻工业出版社,1997.
德尼尔S P,霍奇 N A,戈尔曼 S P .药物微生物学 [M].司书毅,洪斌,余利岩,译.7版.北京:化学工业出版社,生物医药出版分社,2007.