A Study of the Time Effect of the Influence of Electret on Rat Skin Structure

LIANG  Yuan-Yuan; DONG  Fa-Jie; MA  Lin; CUI  Li-Li; LIU  Hong-Yue; JIANG  Jian

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A Study of the Time Effect of the Influence of Electret on Rat Skin Structure

更新时间：2026-05-27

- A Study of the Time Effect of the Influence of Electret on Rat Skin Structure
- Vol. 28, Issue 2, Pages: 88-90(2011)
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- Online First：25 June 2011，
  
  Published：2011
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梁媛媛, 董法杰, 马琳, 崔黎丽, 刘鸿越, 江键. 驻极体对大鼠皮肤显微结构影响的时间效应研究[J]. 广东工业大学学报, 2011, 28(2): 88-90.

LIANG Yuan-Yuan, DONG Fa-Jie, MA Lin, et al. A Study of the Time Effect of the Influence of Electret on Rat Skin Structure[J]. 2011, 28(2): 88-90.
梁媛媛, 董法杰, 马琳, 崔黎丽, 刘鸿越, 江键. 驻极体对大鼠皮肤显微结构影响的时间效应研究[J]. 广东工业大学学报, 2011, 28(2): 88-90. DOI：

LIANG Yuan-Yuan, DONG Fa-Jie, MA Lin, et al. A Study of the Time Effect of the Influence of Electret on Rat Skin Structure[J]. 2011, 28(2): 88-90. DOI：

摘要

利用恒压电晕充电技术制备±1 000 V聚丙烯驻极体，通过倒置相差显微镜观察±1 000 V聚丙烯驻极体作用大鼠腹部皮肤不同时间后大鼠皮肤显微结构的改变，比较驻极体在不同时间点对皮肤显微结构的影响.结果显示：正负极性驻极体长时间作用于大鼠皮肤后，大鼠皮肤显微结构的变化趋势基本一致，表明驻极体长时间作用均可引起鼠皮角质层不同程度脱落，达到减弱皮肤屏障、促进药物经皮吸收的目的.负极性驻极体对大鼠皮肤的作用与正极性驻极体作用相比有较短的时间延迟效应.

Abstract

The ±1 000 V polypropylene (PP) electrets were prepared by means of the corona charging method. To compare the skin microstructure after the application of electret at different time points，the changes in the skin structure were observed after the application of ±1 000 V PP electrets on rat abdominal skin with the inverted phase contrast microscope. The results indicate that both the positive and negative PP electrets can change the microstructure of rat skin and the changes in the skin structure are basically the same. Therefore

skin stratum corneum can fall off in varying degrees after the application of electret for a long time. Electret can be used in transdermal delivery formulation to reduce the barrier function of skin and increase the drug permeation through skin. Compared with +1 000 V PP electret

-1 000 V PP electret has the delaying effect for a shorter time.

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references

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夏钟福.驻极体[M].北京：科学出版社，2001.

许景蜂.药物经皮离子导入与皮肤电化学的研究进展[J]. 解放军药学学报，2003，l9（4）:283-285.

Murthy N S, Boguda V A, Payasada K. Electret enhances transdermal drug permeation[J].Bio Pharm Bull, 2008, 31: 99-102.

梁媛媛，江键，程亮，等.负极性聚丙烯驻极体美洛昔康贴剂对大鼠皮肤结构的影响[J]．解剖学杂志，2009，32（4）：502-505.

马琳，梁媛媛，江键，等.不同极性聚丙烯驻极体对皮肤结构影响的比较研究[C]∥第七届中国功能材料及其应用学术会议论文集．重庆：《功能材料》期刊社，2010：158-160.

徐月红,徐莲英,陶建生. 改善经皮给药系统性能的方法和技术[J]. 药学进展, 2001, 25(5):274-279.

陈芳，王浩，侯惠民.电致孔技术在透皮给药中的应用[J].中国医药工业杂志，2004，35(3)：174-180.

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